Study on the Mechanism of Zhilong Huoxue Tongyu Capsule in the Treatment of Ischemic Stroke Based on Network Pharmacology and Molecular Docking Technology

This study aimed to elucidate the potential pharmacological mechanism of Zhilong Huoxue Tongyu capsule on ischemic stroke through network pharmacology and molecular docking technology. Traditional Chinese medicine system analysis platform bioinformatics tool for traditional databases were used screen active ingredients targets stroke-related screened by GeneCards, online human Mendelian inheritance database, PharmGKB therapeutic target databases. By taking intersection drugs disease targets, possible in treatment obtained, regulatory diagram drugs-active ingredients-targets was drawn genes imported into search retrieval interacting genes/proteins Cytoscape draw protein-protein interaction diagram; gene ontology Kyoto encyclopedia genomes enrichment performed intersecting predict related biological functions signaling pathways. Finally, key compounds obtained screening docking. Quercetin, crocetin, luteolin ursolic acid have highest degree value they are five most important ingredients. The top 5 albumin, tumor necrosis factor, AKT serine/threonine kinase 1, insulin interleukin-1 beta. could treat interleukin-17 pathway, factor mitogen-activated protein toll-like receptor calcitonin receptor-like pathway other Our uses methods basic effects mechanisms stroke, which provides a certain basis next experimental verification research group.